CHEMICAL CONSTITUENTS FROM THE BIOACTIVE ETHYL ACETATE FRACTION OF XANTHIUM STRUMARIUM LINN.

Abstract

The ethyl acetate fraction of Xanthium strumarium Linn. was found possessing antioxidant and antimicrobial potential. It showed significant in vitro antioxidant activity (EC50= 937 µg/mL) in contrast of ascorbic acid as standard. It also exhibited moderate to high antibacterial and antifungal activities having zone of inhibition in range of 12-34 mm against pathogenic microorganism. Two pentacyclic triterpenes ?- amyrin (1), oleanolic acid (2) and an aromatic acid, ferulic acid (3) have been isolated from this bioactive ethyl acetate (EtOAc) fraction of Xanthium strumarium Linn. The structures of these compounds were elucidated through various spectroscopic techniques such as IR, EIMS and 1H-NMR techniques.