REPEATED ORAL ADMINISTRATION OF FLAXSEEDS INDUCED ANTIDEPRESSANT AND ANXIOLYTIC EFFECTS IN RATS

Abstract

Omega-3- fatty acids found in flaxseed is good for maintaining brain health as about 60 percent of the brain consists of lipids (fats) which make up the lining, or cell membrane, of every brain cell. The types of fats present in the brain influence its structure and functions, Flaxseeds are the richest plant source of omega-3 fatty acid (?linolenic acid) and the phytohormone lignans. It is also an essential source of high-quality protein and dietary fiber. Additionally, flaxseed has potential to be a source of phenolic compounds. The present study was designed to investigate the effects of flaxseeds from neurobehavioral aspects. The effect of oral intake of flaxseeds was also monitored on glucose and cholesterol level. Flaxseeds were given orally to rats for a period of 4 weeks. Open field apparatus used to monitor locomotor activity, forced swim test to assess depression like symptoms and elevated plus maze to determine anxiogenic behaviors. Significant changes were observed in open field activity. A significant decrease in depression like symptoms and anxiety were also exhibited by test rats as compared to the control rats while significant improvement in memory was observed in flax treated rats. Flax seeds treated rats also exhibited a significant decrease in glucose and cholesterol level.