PREEMPTIVE EFFECT OF PANAX GINSENG EXTRACT ON SENSORIMOTOR DYSFUNCTION IN EXPERIMENTALLY INDUCED MIDDLE CEREBRAL ARTERY OCCLUSION-REPERFUSION INJURY MODEL OF ISCHEMIC STROKE.
Abstract
Present study aims to investigate the protective effects of Panax ginseng extract (PGE) following middle cerebral artery occlusion/reperfusion (MCAO/R) model in relation to post-stroke neurobehavioral changes.
Age and sex-matched Wistar rats of body weight 200 ± 20g were randomly divided as group I- (control group), group II (sham group), group III (MCAO/R, stroke group) and group IV (MCAO+PGE treated group). Group IV animals were orally administered with panax ginseng extract 10mL/day for thirty days. After one month MCAO/R surgery was employed to group IV animals. At the end of experimental period, all groups were tested for ischemic stroke-related sensorimotor changes via battery of neurobehavioral tests including neurological deficit score, corner turn test, vibrissae-evoked forelimb placing test (a) ipsilesional limb and (b) contralesional limb placement, foot-fault test and wire-hanging maneuver.
PGE treatment showed consistent and significant (P<0.05) improvement in neurobehavioral activities following MCAO/R injury as expressed by significant reduction in ND score, significant improvement in contralesional & ipsilesional forelimb placement, foot faults, corner?turn and wire hanging maneuver.
PGE consumption has significant protective effect against ischemia-reperfusion associated neuronal injury as assessed by recovery of neurobehavioral functions.
