NEUROCHEMICAL AND BEHAVIORAL EFFECTS OF SYNTHETIC ADRENERGIC AND RELATED COMPOUNDS ON RATS

Abstract

The present study concerns neurochemical and behavioral effects of piperidine substituted 2 chloro 3, 4, dihydroxyacetophenone derivative compounds.Intraperitonial injection in rats significantly increases locomotors activity in open field experiment, anxiolytic effects of the newly synthesized compounds observed in light and dark apparatus were significantly increased, suggesting the anxiolytic effects of piperidine substituted 2 chloro 3, 4, dihydroxyacetophenone derivative. Moreover, stimulatory activity of compounds observed in Home cage apparatus which was significantly increased. Neurochemicals effects were observed by HPLC-EC, which showed that after administration of compound (I) (II) increased the level of dopamine in rats brain. Suggested that these piperidine substituted 2 chloro 3, 4, dihydroxyacetophenone derivative compounds may be effective as a drug for treatment of depression, enhancement of locomotion and stimulation. Further studies using animal’s models of depression are required to establish these drugs.