IN VITRO LEISHMANICIDAL ACTIVITY OF 1,3-DISUBSTITUTED UREA

Authors

  • SANA MUSTAFA University of Karachi, Karachi-75270, Pakistan
  • SHAHNAZ PERVEEN Department of Chemistry,

Abstract

Protozoan parasites are among the most common pathogens. Leishmania affects large populations of the world especially in the third world countries including Pakistan. We attempted to assess synthesized 1,3- disubstituted ureas for leishmanicidal activity. Compounds, N-(2,6-dimethylphenyl)-N’-(2-nitrophenyl) urea and N-butyl-N’-(4-nitrophenyl)urea showed pronounced inhibition with IC50 + S.D (?g/mL) of 29.16 + 1.04 and 40.91 + 0.12, respectively

Author Biographies

SANA MUSTAFA, University of Karachi, Karachi-75270, Pakistan

Department of Chemistry,

SHAHNAZ PERVEEN, Department of Chemistry,

Federal Urdu University for Arts, Science and Technology,
Gulshan-e-Iqbal Campus, Karachi-Pakistan

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Published

2012-12-20

Issue

Vol. 2 No. 2 December (2012): Fuuast Journal of Biology

Section

Articles