EVALUATION OF ANTHELMINTIC ACTIVITY OF DIFFERENT FRACTIONS OF SYZYGIUM CUMINI L. LEAVES

Abstract

Syzygium cumini L. (Jamun), member of family ?Myrtaceae” is a well-known medicinal plant. It is also known for its anthelmintic activity by which it can paralyze the worms leading to their death. Current study was conducted to evaluate anthelmintic activity of methanolic extract of S. cumini L. leaves against earthworms (Lumbricus terestris), Tape worms (Monnizia expansa) and Red worms (Haemonchus contortus). Research was conducted at Department of Botany, Lahore College for Women University, Lahore. The experiment was repeated for three times for accuracy and then average data was statistically analyzed using Ducan’s Multiple Range Test. Various concentrations of each extract (100, 50, 25, 12.5 and 6.25 %), Albendazole (10%) and saline solution (10%) were used as treatments. All the tested concentrations were significant to kill the worms used in experiment. Maximum activity of methanolic extract of S. cumini leaves was 8 minutes as time of paralysis, 15 minutes as time of death at dose of 100 mg/ml. Saline solution used as control, there was no paralysis and death of worms in this case.The result of current study indicated that all tested extract of S. cumini L. show anthelmintic activity in a dose depended inhibition. The effectiveness of test sample was found to be reversible to time of paralysis and death time of worms. Albendazole (10 mg/ml) was used as reference. All the concentration of S. cumini L. extract possessed good anthelmintic activity as compared to Albendazole. Thus, the study concluded that the methanolic extracts of S.cumini L. have good anthelmintic activity against all the worms used in study. Key words: Albendazole, Anthelmintic, Lumbricus terestris, Monnizia expansa, Haemonchus contortus, Syzygium cumini