EXTRACT OF OLIVE (OLEA EUROPAEA L.) CURES HEMATOLOGIC TOXICOSIS INDUCED BY DOXORUBICIN

Abstract

The protective effects of extract of Olea europaea L was evaluated in hematological toxicosis induced by Doxorubicin (DOX). Standard Soxhlet apparatus was used to prepare ethanolic extract of Olea europaea L leaves. Eighteen Wister rats (male) were incorporated in the study and divided in 3 groups: T* (control group: 2 ml 0.9 % Normal Saline), TP0 (DOX group: 15 mg/kg) and TP1 (extract of Olea europaea L + DOX: 200 + 15 mg/kg). The drugs were administered by intra peritoneal route. Blood was withdrawn on 57th day by cardiac puncture and preserved for analysis. Hematological profile included CBC and Platelet count. Hematological analysis revealed that the animals which received Doxorubicin had low levels of Hemoglobin, RBCs, Leukocytes, Neutrophils, Eosinophils, Monocytes, Lymphocytes and Platelets when compared to control group which received normal saline. The levels of Hb and RBCs were low but not manifested in anemia. Neutrophil and Platelet count were drastically low, which shows positive sign of Neutropenia and Thrombocytopenia. The treated group animals which receive extract + DOX showed positive elevation in the levels of CBC and Platelet count. On the basis of hematological report it is concluded that combination of extract of Olea europaea L can prevent the toxicosis effects of Doxorubicin.