BENZIMIDAZOLE DERIVATIVES WITH POTENTIAL CYTOTOXIC ACTIVITY -SYNTHESIS AND THEIR STRUCTURE-ACTIVITY RELATIONSHIP

Authors

  • ARFA KAMIL Federal Urdu University of Arts Sciences and Technology, Gulshan-e- Iqbal Campus, Karachi-Pakistan.
  • SHAMIM AKHTAR University of Karachi, Karachi-Pakistan.
  • ANEELA KARIM Federal Urdu University of Arts Sciences and Technology, Gulshan-e- Iqbal Campus, Karachi-Pakistan.
  • AHSAAN AHMED University of Karachi, Karachi-Pakistan.
  • MEHWISH WAJDI Federal Urdu University of Arts Sciences and Technology, Gulshan-e- Iqbal Campus, Karachi-Pakistan.
  • ZAHID KHAN Federal Urdu University of Arts Sciences and Technology, Gulshan-e- Iqbal Campus, Karachi-Pakistan.
  • ZAHID KHAN Federal Urdu University of Arts Sciences and Technology, Gulshan-e- Iqbal Campus, Karachi-Pakistan.
  • SAEED SAIFY International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.

Abstract

Benzimidazole is an important class of compounds with a wide spectrum of biological activity. This five membered heterocyclic moiety confer for various biological activities. In this study, we prepared some benzimidazole derivatives of 2-(2´-pyridyl) benzimidazole and investigated their cytotoxic effect. The structure of the synthesized analogs were characterized by UV, IR and 1H NMR spectral data and evaluated for their cytotoxic effect.

Author Biographies

ARFA KAMIL, Federal Urdu University of Arts Sciences and Technology, Gulshan-e- Iqbal Campus, Karachi-Pakistan.

Department of Pharmaceutical Chemistry,

SHAMIM AKHTAR, University of Karachi, Karachi-Pakistan.

Department of Pharmaceutical Chemistry, 

ANEELA KARIM, Federal Urdu University of Arts Sciences and Technology, Gulshan-e- Iqbal Campus, Karachi-Pakistan.

Department of Pharmaceutical Chemistry,

AHSAAN AHMED, University of Karachi, Karachi-Pakistan.

Department of Pharmaceutical Chemistry, 

MEHWISH WAJDI, Federal Urdu University of Arts Sciences and Technology, Gulshan-e- Iqbal Campus, Karachi-Pakistan.

Department of Pharmaceutical Chemistry,

ZAHID KHAN, Federal Urdu University of Arts Sciences and Technology, Gulshan-e- Iqbal Campus, Karachi-Pakistan.

Department of Pharmaceutical Chemistry,

ZAHID KHAN, Federal Urdu University of Arts Sciences and Technology, Gulshan-e- Iqbal Campus, Karachi-Pakistan.

Department of Pharmaceutical Chemistry,

SAEED SAIFY, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.

H.E.J. Research Institute of Chemistry,

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Published

2013-12-29

Issue

Vol. 3 No. 2 (2013): Volume 3 (2) December, 2013

Section

Articles