DETERMINATION OF HYPERLACTATEMIA AND ACIDOSIS IN ADULT PATIENTS WITH CARDIAC DISEASES AND DYSFUNCTIONS

Authors

  • JUNAID MAHMOOD ALAM Liaquat National Hospital and Medical College, Karachi-Pakistan
  • ZIA-UL ISLAM Bahria Medical and Dental College, Bahria University, Karachi-Pakistan
  • SIKANDER KHAN SHERWANI Federal Urdu University of Science and Technology, Karachi-Pakistan
  • SARAH SUGHRA ASHGAR Govt. Lyari General Hospital, Karachi-Pakistan
  • SYED RIAZ MAHMOOD Govt. Lyari General Hospital, Karachi-Pakistan
  • ISHRAT SULTANA Liaquat National Hospital and Medical College, Karachi-Pakistan
  • MAQSOOD ALI ANSARI University of Karachi, Karachi-Pakistan

Abstract

It has been postulated that acidosis, which is co-morbid in cardiac dysfunctions usually not occurs only due to high lactate concentration in blood (hyperlactatemia), but some other components such as un-measured anions are known to significantly induce characteristic acidemia in patients also contribute to it. The present study describes the determination of different components of metabolic acidosis in cardiac dysfunction and cardiac arrest patients in order to assess the degree to which lactate is responsible for the acidosis. Fifty five adult patients with cardiac dysfunctions and cardiac arrest who were brought to the hospital for treatment or admitted to the hospital were included in present study. All biochemical, blood gases and related parameters were determined by standard methods using auto-analyzers. Stewart's (1983) quantitative biophysical methods and formula were used for apparent strong ion difference “SIDa” and strong ionic gap “SIG”, to evaluate unmeasured and measured ions. The average age of the patients was 58.4 years, including 39 (70.90%) males and 16 (29.09%) females. All assessed variables were found significantly different between the two groups, except the concentration of sodium, ionized calcium and SIDa. Cardiac dysfunction patients also showed low potassium (hyperkalemia) and chloride (hypochloremia) and elevated lactate concentration (hyperlactatemia) in blood, whereas higher anion gap and SIG were also noted to be manifested. Lactate as an independent component was observed to be a notable assessor of acidemia. It was concluded that although lactate accounts for only less than 50% of acidemia it did influence the occurrence of metabolic acidosis and subsequent acidemia in patients. Moreover, amplification in unmeasured anions (SIG) and phosphate is also related to the major portion of acidemia.

Author Biographies

JUNAID MAHMOOD ALAM, Liaquat National Hospital and Medical College, Karachi-Pakistan

Department of Biochemistry and Biochemistry Laboratory Services,

ZIA-UL ISLAM, Bahria Medical and Dental College, Bahria University, Karachi-Pakistan

Departments of Anatomy,

SIKANDER KHAN SHERWANI, Federal Urdu University of Science and Technology, Karachi-Pakistan

Department of Microbiology,

SARAH SUGHRA ASHGAR, Govt. Lyari General Hospital, Karachi-Pakistan

Department of Pathology,

SYED RIAZ MAHMOOD, Govt. Lyari General Hospital, Karachi-Pakistan

Department of Pathology,

ISHRAT SULTANA, Liaquat National Hospital and Medical College, Karachi-Pakistan

Biochemistry Laboratory Services,

MAQSOOD ALI ANSARI, University of Karachi, Karachi-Pakistan

Department of Genetics

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Published

2012-12-20